A.Publications

1.Hsien-Yuan Lane; Cheng-Chieh Lin; Chiung-Hsien Huang ; Yue-Cune Chang; Shih-Kuan Hsu; and Wen-Ho Chang, Risperidone response and 5-HT₆ receptor gene variance: genetic association analysis with adjustment for nongenetic confounders, Schizophrenia Research, V67, 63-70, (2004).

2.Hsien-Yuan Lane, Yue-Cune Chang, Chih-Chiang Chiu, Sue-Hong Lee, Cher-Yeang Lin, Wen-Ho Chang, Fine-tuning risperidone dosage for acute schizophrenia: clinical determinants, Psychopharmacology (in press), (2003).

3.Rey-Heng Hu, Po-Huang Lee, Yue-Cune Chang, Sen-Chang Yu, Ming-Chih Ho. and Yao-Ming Wu, Treatment of centrally located hepatocellular carcinoma by central hepatectomy, Surgery, V133, 251-256, (2003).

4.Rey-Heng Hu, Po-Huang Lee , Yue-Cune Chang, Sen-Chang Yu, Ming-Chih Ho. And Yao-Ming Wu, Prognostic Factors for Hepatocellular Carcinoma ≦ 3cm in Diameter, Hepato-Gastroenterology, V50, 2043-2048, (2003).

5.Hsien-Yuan Lane, Yue-Cune Chang, Chieh-Liang Huang, Wen-Ho Chang, Refining pharmacogenetic research in schizophrenia: Control for patient-related variables, Drug Development Research, V60, 164-171, (2003).

6.Guo-Shu Huang, Wing P. Chan, Yue-Cune Chang, Cheng-Yen Chang, Cheng-Yu Chen, and Joseph S. Yu, MR Imaging Assessment of Bone Marrow Edema and Joint Effusion in Patients with Osteonecrosis of the Femoral Head: Relationship to Pain, AJR, V181, 545-549, (2003).

7.Tien-Yow Chuang, Ken-Jen Yu, I-Wen Penn, Yue-Cune Chang, Pei-Hsin Lin, and Yun-An Tsai, Neurourological Changes Before and After Radical Hysterectomy In Patients With Cervical Cancer, Acta Obstetricia et Gynecologica Scandinavica, V82, 954-959, (2003).

8.Hsien-Yuan Lane; Yue-Cune Chang; Yiao-Cheung Cheng; Guang-Chyi Liu; Xing-Ru Lin; and Wen-Ho Chang, Effects of patient demographics, risperidone dosage, and clinical outcome on body weight in acutely exacerbated schizophrenia patients, Journal of Clinical Psychiatry, 316-320, (2003).

9.Ming-Chuan Chang, Yue-Cune Chang, Jeng-Fong Chiou, Tsung-Shan Tsou, Chia-Chin Lin, Overcoming Patient-related Barriers to Cancer Pain Management for Home Care Patients: A Pilot Study, Cancer Nursing, V 25, 470-476, (2002).

10.W.P. Chan, Y.-J. Liu, G.-S. Huang, C.-C. Jiang, S. Huang, and Y.-C. Chang, MRI of joint fluid in femoral head osteonecrosis, Skeletal Radiol, V31, 624-630, (2002).

11.Tien-Yow Chuang, Ming-Chao Huang, Kuo-Chih Chen, Yue-Cune Chang, Yu-Shu Yen, Liang-Shong Lee b, Henrich Cheng, Forelimb muscle activity following nerve graft repair of ventral roots in the rat cervical spinal cord, Life Science, V71, 487-496, (2002).

12.Hsien-Yuan Lane; Yue-Cune Chang; Chih-Chiang Chiu; Mao-Liang Chen; Min-Hua Hsieh;

    Wen-Ho Chang, Association of Risperidone Treatment Response With a Polymorphism 

     in the 5-HT2A Receptor Gene, Am J Psychiatry, 159, 1591-1595, (2002).

13.Hsien-Yuan Lane; Yue-Cune Chang; Chi-Chiang Chiu; Tzu-Ting Chen; Sue-Hong Lee;

    Wen-Ho Chang, Influences of Patient-Related Variables on Risperidone Efficacy 

     for Acutely Exacerbated Schizophrenia: Analyses With Rigorous Statistics, Journal

      of Clinical Psychopharmacology, 22, 353-358, (2002).

14.Kwan-Hwa Chi; Yue-Cune Chang; Wan-Yao Guo; Mei-Jung Leung; Cheng-Yin Shiau; Sheng-Yu

    Chen; Ling-Wei Wang; Yuen-Liang Lai; Mau-Min Hsu; Shi-Long Lian; Ching-Hsiung Chang; 

     Tsang-Wu Liu; Yung-Hsin Chin; Sang-Hue Yen; Cheng-Hang Perng; Kuang Y. Chen,

      A Phase III Study of Adjuvant Chemotherapy in Advanced Nasopharyngeal Carcioma 

       Patients, Int. J. Radiation Oncology Biology Physics, 52, 1238-1244,(2002).

15.Hsien-Yuan Lane; Yue-Cune Chang; Muh-Hwan Su; Chi-Chiang Chiu; Ming-Chyi Huang; 

    Wen-Ho Chang; Shifting from Haloperidol to Risperidone for Behavioral Disturbances

      in Dementia: Safety, Response Predictors, and Mood Effects,  Journal of Clinical

       Psychopharmacology, 22, 4-10, (2002).

16.Ning-Huei Peng, Hsin-Chun Mao, Yueh-Chih Chen and Yue-Cune Chang, Effects of Light Intensity on the Physiological Parameters of the premature Infant, (in Chinese, with English Abstract), The Journal of Nursing Research, V9, 333-343, (2001).

17.Hsien-Yuan Lane, Michael W Jann, Yue-Cune Chang, Chih-Chiang Chiu, Ming-Chyi Huang, Sue-Hong Lee, and Wen-Ho Chang, Repeated Ingestion of Grapefruit Juice Dose Not Alter Clozapine’s Steady-State Plasma Levels, Effectiveness, and Tolerability, Journal of Clinical Psychiatry, V62, 812-817. (2001).

18.I-Hui Lee, Bing-Wen Soong, Yi-Chun Lu, and Yue-Cune Chang, Dentatorubropallidoluysian Atrophy in Chinese, Arch Neurol, V 58, 1905-1908. (2001).

19.Chang, Yue-cune; Perng, Cheng-hwang; Shiau, Cheng-ying, On Estimating Stratified 

    PH Model with Single Covariate from Sparse Data with Application to Brain 

     Metastases Study. Biometrical Journal, 42, 157-169, (2000).

20.Chang, Y. C., Detection of human cytomegalovirus retinitis and monitoring of 

ganciclovir treatment using conjunctival swab with polymerase chain reaction in

     AIDS  patients. International Journal of STD and AIDS, 11, 85-91, (2000).

21.Chang, Yue-cune, Gamma knife radiosurgery as a single treatment modality for large 

    cerebral  arteriovenous malformations. Journal of Neurosurgery, 93, suppl.3,

    113-119, (2000).

22.Chang, Yue-cuneb Butach, a Suspected Carcinogen, Alters Growth and Transformation

    Characteristics of Mouse Liver Cells. Chemical Research in Toxicology. 13,

    1321-1325, (2000).

23.Chang, Y. C., Residuals analysis of the generalized linear models for longitudinal 

    data. Statistics in medicine, 19, pt.10, 1277-1294, (2000).

24.Jiang, Shun-yuan; Shen, Shyue-ren; Shyu, Rong-yaun; Yu, Jrh-cheng; Harn,Horng-jyh;

    Yeh, Ming-yang; Lee, May Mei-shyuan; Chang, Yue-cune, Expression of nuclear 

     retinoid receptors in normal, premalignant and malignant gastric tissues 

      determined by in situ hybridization. British journal of cancer, 80, no.1, 206-214, 

      (1999).

25.Lane, Hsien-yuan; Chang, Yue-cune; Chang, Wen-ho; Lin, Shin-ku;Tseng, Yung-te;

    Jann, Michael W., Effects of gender and age on plasma levels of clozpine and its 

     metabolites: analyzed by critical statistics. Journal of clinical psychiatry,

      60, no.1, 36-40, (1999).

26.Guo, W. Y.; Pan, H. C.; Shiau, C. Y.;Chang, Y. C.; Wu, H. M.;Chung, W. Y.; Wang, 

     L. W.; Teng, M. M. H., AVM radiosurgery : where is the volume limit? Rivista di 

      neuroradiologia, 12, suppl.2, 35-40, (1999).

27.Chen, Chiao-chicy; Lu, ru-band; Chen, Yi-chyan; Wang, Ming-fang;Chang, Yue-cune; Li,

    Ting-kai; Yin, Shih-juin, Interaction between the functional polymorphisms of the 

     alcoholmetabolism genes in peotection against alcoholism. American journal of 

      human genetics, 65, 795-807, (1999).

28.Chen, Yi-chyan; Lu, Jang-jih; Peng, Giia-sheun; Wang, Ming-fang; Wang, Hsu-kun; 

     Ko, Huei-chen; Chang, Yue-cune; Lu, Jang-jih; Li, Ting-kai; Yin, Shih-juin,

     Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous 

      for the ALDH2*2 variant gene allele, Alcoholism: clinical and experimental 

        research, 23, no.12, 1853-1860, (1999).

29.Pan, D. H. C.; Guo, W. Y.; Chang, Y. C.; Chung, W. Y.; Shiau, C. Y.; Wang, L. W.;

     Wu, S. M., Effects of gamma knife radiosurgery for brain tumors : clinical 

      evaluation. Chinese medical journal (Taipei), 61, no.7,397-407, (1998).

30.Pan, D. H. C.; Guo, W. Y.; Chang, Y. C.; Chung, W. Y.; Shiau, C. Y.; Wang, L. 

    W.; Wu, S. M., The effectiveness and factors related to treatment results of 

     gamma knife radiosurgery for meningiomas. Stereotactic and functional 

      neurosurgery, 70, no.1, 19-32, (1998).

31.孫建安; 張玉坤; 賴錦皇; 吳德敏; 劉紹興.實驗室測量血中鉛含量一致性的評估:國人血中鉛濃度

    調查研究的經驗. 中華民國衛生雜誌, 17, no.2, 103-110,(1998).

32.Lane, Hsien-yuan; Chang, Wen-ho; Chang, Yue-cune; Hu, Oliver Yao-pu; Lin, Hsin-nan; 

    Jann, Michael W.; Hu, Wei-herng, Dose-dependent reduced haloperidol/haloperidol 

     tatios : nfluence of patient-related variables. Psychiatry research, 72, no.2, 

      127-132, (1997).

33.Chang, Yue-cune, GEE之敏感度分析:偵測高影響之觀察值. 中華公共衛生雜誌,15, no5, 403-410,

    (1996).

34.Chang, Yue-cune,生物統計方法在分析醫學及公衛資料上之困惑:廣義線性模型方面. 

    中華民國家庭醫學雜誌, 6, no.2, 59-74, (1996).

35.Shiau, Y. Y.; Chang, H. F.;Chang, Y. C., Observation of bolus position with 

    standardized test foods and fluoroscopic technique. Journal of oral rehabilitation, 

    23, no.9, 607-614, (1996).

36.Chang, Yue-cune; Liang, Kung-yee, Estimation in the Exponential Family in the 

    Presence of Nuisance Parameters : Compromise between Bias and Precision.

     Statistica Sinica, 4, no.1, 169-185, (1994).

37.Chang, Yue-cune; Liang, K. Y.; Self, S. G, Modeling Marginal Hazards in Multivariate

    Failure Time Data. Journal of the Royall Statistical Society, Series B, 55, no.2,

    441-453, (1993).

38.Chang, Yue-cune, Familial Aggregation of Periodontal Indices. Journal of Dental 

    Research. 72, 544-551, (1993).  

39.Yue-Cune Chang, The Trade-off between Bias and Precision: Some Statistical Considerations, Ph.D. Thesis, Department of Biostatistics, School of Hygiene & Public Health, The Johns Hopkins University, (1992).

40.Cheng, P.E. and Chang, Y.C., PLE verse MLE of SurvivorFunctions under a Simple Proportional Hazard Model. J. of Chinese Stat. Ass., 23, 57-73, (1985).

1. NSC88-2118-M032-003  Evaluate the Treatment Effects of Gamma Knife Stereotactic        Radiosurgery for Intracerebral Arteriovenous Malformation

2. NSC89-2118-M032-011  The Necessity of Angiography Examination for AVM Patients after GK   Surgery---From Biostatistics Point of View

3. NSC89-2118-M032-022  The Analysis of Multi-State Survival Data: Application to a Study of Cerebral Palsy Children

4. NSC90-2118-M032-004  Evaluate the Brain Function of AVM Patients after Treated by Gamma Knife

5. NSC91-2118-M032-006  Prediction Models for AVM Patients Intended to Treat by Gamma Knife